Akuamma, otherwise known as Picralima Nitida, comes from a shrub like tree (similar in height to Kratom plants) that flourishes along the riverbanks in West Africa. The main alkaloids present in Akuamma seeds are Akuammine and Pericine – which are both comparable to Mitragynine in Kratom.

Because Akuamma are so similar in many ways – the effects of taking Akuamma Seed are also very similar to consuming Kratom leaves.

The main alkaloids making the plant highly potent and effective include;

• Akuammidine- this is the seeds’ main alkaloid and works by influencing opioid binding sites. The alkaloid provides analgesic qualities to help in eradicating pain as well as serving as a muscle relaxant.
• Akuammine- this alkaloid has a higher affinity for mu-opioid binding sites, unlike the Akuammidine. It helps with providing analgesic effects, however, may cause an inhibitory impact on the peristaltic movement of the intestines if used in higher doses.
• Akuammicine- this alkaloid, on the other hand, has a higher affinity for kappa-opioid binding sites.
• Pseudo-Akuammigine- this alkaloid provides both anti-inflammatory and analgesic effects. Depending on the dosage, the alkaloid excites, modulates the skeletal muscle contraction, smooth muscle contraction, central nervous system, and respiration.
• Akuammigine- this one has only shown to have an anti-adrenergic effect on blood vessels as well as the heart.
• Pericine- this one has been indicated to bind to mu-opioid receptors, however, may cause convulsions resulting in involuntary contraction of muscles.

Akuamma is today considered as a better alternative to other harsh substances as it guarantees holistic pain relief. This has further prompted extensive medical research on the plant to understand the integrity of its medical value better. Among the many health benefits of akuamma include;

1) Anti-Malarial Activity

The active alkaloid, Akuammine is responsible for the anti-malarial activity. This makes akuamma one of the strongest anti-malarial herbs used all over the world. Extracts from akuamma seeds, stem bark, and fruit rind have been indicated to have inhibitory activity against drug-resistant Plasmodium falciparum thus supporting the fact that the herb is a potential anti-malarial drug.

2) Trypanocidal Activity

Akuamma seeds are known to have an anti-parasitic effect on specific parasites especially Trypanosoma, which is a parasitic protozoan causing various ailments like sleeping sickness among others. Scientific studies have also proved the trypanocidal effects of akuamma seeds.

3) Anti-Leishmanial Activity

Picralima Nitida is one of the plants whose extracts have been evaluated for anti-leishmanial activity using a mechanism-based radiorespirometric microtechnique and results confirmed activity against Leishmania donovani at 50 or fewer micrograms/ml.

4) Antipyretic Activity

According to a preliminary pharmacological study on the methanolic extract of akuamma, the results showed potent and dose-dependent antipyretic activity with higher mean percentage Antipyrexia (38.7%) compared to that of aspirin (29.0%). This medicinal value of this herb justifies why it is still common in many countries in W. Africa.

5) Analgesic Activity

The alkaloids extracted from akuamma have been indicated to have opioid analgesic activity. Over time, individuals have turned to use akuamma seed to get rid of the pain caused by such conditions as migraines, fibromyalgia, and arthritis among others effectively.

It is even regarded as a better alternative to opiates that come with withdrawal side effects and addiction. The seeds from this plant are purely natural and have very few side effects. You may as well take the seeds for sore muscles to get immediate pain relief after roughly 15-30 minutes.

6) Anti-Inflammatory Activity

Alkaloid extracts from akuamma have been investigated for anti-inflammatory activity and results indicated that pseudo-Akuammigine significantly reduced the mean maximal and total swelling after oral administration of the alkaloid.

7) Anti-Diarrhoeal Activity

Akuamma plant has been widely used traditionally in the W. African countries to cure many health conditions including dysentery among other gastrointestinal disorders.

According to a study to determine the anti-shigellosis activity of the methanol extract of akuamma on Shigella dysenteriae type 1 induced diarrhea in rats, it was observed that the extract had antimicrobial effects on eleven out of the 17 pathogenic strains tested.

The extract remarkably reduced the frequency of feces released. From these findings, it is evident that Picralima Nitida extracts are very effective in eliminating gastrointestinal disorders like diarrhea.

8) Antioxidant and Anti-Diabetic Activities

Diabetes Mellitus is a common metabolic condition usually associated with oxidative stress and characterized by chronic hyperglycemia.

According to medical studies investigating the antioxidant and ant-diabetic potential of methanol extracts of the leaves and stems of akuamma plant, it was observed that the methanol leaf extract of the herb exhibited remarkable hypoglycemia activity with roughly 38% of glycemia reduction thanks to the alkaloid-akuammicine, which is believed to promote glucose uptake of the cells, thus reducing the level of glucose in the bloodstream.

From these findings, it is evident that akuamma plant has both antioxidant and anti-diabetic properties hence can be used to effectively treat diabetes mellitus as well as serve as the basis upon which new and powerful drugs can be developed to help in the treatment of diabetes and related health conditions.

9) Sedative Activity

The seed extracts of this herb are known to minimize stress and anxiety to give one a calming, soothing, and generally relaxing effect. It has also been indicated to help counter panic attacks whereas it is also considered for sedation purposes by people who experience sleep problems like insomnia and nightmares.

The seeds have strong sedative properties hence guarantee the most peaceful sleep if taken just before bedtime. It is also reported that the calming effects of the herb will be experienced almost immediately allowing you to enjoy a good rest free of pain, stress or anxiety.

10) Anti-Ulcer Activity

A study evaluating the anti-ulcer activity of the methanol extract, methanol fractions and chloroform of akuamma seeds revealed that the fractions and extracts of the herb produced a remarkable reduction in ulcer index as well as total acidity and pepsin activity.

Instead, an increase in Mucoprotective parameter was established. The ulcer-inhibition property of this herbal plant adds up to the many health benefits the plant is known for.